Endocrine Abstracts

Background: Sulfonylureas (SUs) are known to increase fasting insulin levels in patients with Type 2 Diabetes (T2D) treated with these agents. Whether this increase is related to a greater risk of hypoglycemia has not yet been sufficiently elucidated.Methods: The study included 58 patients with T2D who had been on treatment with SUs, but not insulin, for more than 2 years. Confirmed hypoglycemic episodes during the past year were self-reported by the pat...

Background and Aims: Our objective was to assess the association between genetic polymorphisms in TCF7L2, CTRB1/2 and GLP-1R genes and inter-individual variability in response to treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in terms of glycemic control and weight loss among Greek individuals with type 2 diabetes mellitus (T2DM) and to identify potential predictors of response to GLP-1 RA therapy.Material...